THE MICROBIOME
The microbiome is the set of microorganisms (bacteria, fungi, yeasts) living in our body. A human being is made up of an average of 100,000 billion bacteria, which represents approximately 2kg of our total weight. The balance of our microbiome is essential to our health and to preserve the beauty of our skin.
Where are the bacteria located?
Our bacteria are mainly gathered in the intestines, which we now know play a major role in maintaining our immune system. We speak of intestinal microbiota or intestinal flora to define the bacteria located in this area.
We also find bacteria on our skin, which is called skin microbiota or skin flora.
Finally, women have bacteria in their vaginas. This is the vaginal flora, which is essential for the health of infants!
But what are these bacteria for?
The majority of these bacteria are good bacteria. They have several functions: they help us digest, make vitamins, protect us from disease. They even act on our brain and therefore our mood. Their role is to protect our body and our skin from external aggressions. When our microbiome is balanced we are healthy. In case of imbalance, appear diseases, sensitive skin, redness, irritation.
However, we now know that our microbiome is weakened by our contemporary way of life. According to a recent study*, in the West, 1 in 4 individuals out of 100 people studied have an impoverished microbiome.
It is therefore very important to strengthen our microbiome to stay healthy and maintain beautiful and healthy skin.
What factors can cause an imbalance in our microbiome?
Several factors can influence the composition and balance of the microbiota, including certain medications, diet, lifestyle, and environment.
1. ANTIBIOTICS
Antibiotics are medications intended to treat certain bacterial infections. Depending on their spectrum of action, they can also influence the composition of the intestinal microbiota.
2. A VARIED AND FIBER-RICH DIET
Certain dietary fibers can be used by the microorganisms in the intestinal microbiota. A varied and balanced diet helps diversify the nutrient sources available to the microbiota.
3. COSMETIC PRODUCTS AND THE SKIN MICROBIOTA
The products we apply to our skin daily come into contact with its microbiota. Their formulation, pH, and method of use can thus influence the environment in which the microorganisms on its surface live.
This is why the choice of skincare and how it is formulated are important. At DEMAIN Beauty, we develop formulas designed to respect the balance of the skin microbiome, while effectively and sensorially meeting the skin's needs.
This focus on the microbiome is part of our global vision of beauty: preserving the skin’s balance today to support its beauty over time.
4. THE MICROBIOTA, AT THE HEART OF A GLOBAL BALANCE
Research today is increasingly focused on the interactions between our various microbiotas and the rest of the body. Areas being studied include the links between the gut, brain, and skin, sometimes referred to as the gut-brain axis and the gut-skin axis.
Diet, stress, sleep, physical activity, and environment are also among the factors being studied for their influence on the composition and diversity of the microbiota. This research reinforces a more holistic view of the skin: it does not function independently of the rest of the body.
This approach echoes DEMAIN Beauty's Inside/Out philosophy: taking care of your skin from the outside, while considering the diet and lifestyle habits that contribute to our overall well-being. A vision that naturally aligns with our approach to longevity.
Microbiota, skin, gut, brain: research in full evolution
Our skin does not function independently of the rest of our body. Scientific research is increasingly focusing on the interactions between our various microbiotas and our organism, particularly through the gut-skin axis and the gut-brain axis.
This work explores the relationships between the gut microbiota, the skin, and the nervous system, as well as the influence of factors such as diet, stress, sleep, the environment, and even age.
Aging also constitutes an important field of research. The composition of the skin microbiome evolves with age, and scientists are now studying the links between microbiome, skin function, and skin aging.
This research reinforces a more holistic vision of beauty: the skin is part of an organism whose various balances are interconnected.
It is this vision that inspires the Inside/Out approach of DEMAIN Beauty: considering skincare, nutrition, and lifestyle habits all at once.
Taking care of yourself today to age better tomorrow.
Consult scientific studies
Demain Beauty's microbiome-friendly approach
Since its inception, DEMAIN Beauty has placed respect for the skin microbiome at the heart of its approach.
Our skincare, 100% natural in origin and certified organic, combines microbiome science, advanced biotechnologies, and high-performance active ingredients, with a singular goal: to create effective, sensorial, and microbiome-friendly formulas designed to respect the skin’s natural balance.
Depending on the formula, we use, among other things, prebiotics and postbiotics, selected for their value in our formulations and their complementarity with other active ingredients.
TESTING TO BETTER UNDERSTAND THE IMPACT OF OUR FORMULAS
Because microbiome-friendly must be more than just a promise, the majority of our products undergo specific tests to evaluate their respect for the skin microbiome. A large number also hold a microbiome-respect certification.
This approach allows us to integrate microbiome study into the evaluation of our formulas and support their development with a scientific approach.
An approach that combines naturalness, science, efficacy, and pleasure of use.
THE MICROBIOME, ONE PIECE OF A LARGER VISION
At DEMAIN Beauty, caring for the microbiome is part of a more global vision of beauty and longevity, which combines skincare, nutrition, and lifestyle habits.
Our Inside/Out approach is based on a simple conviction: the skin cannot be considered independently of the rest of the body.
Preserve our skin and our body today. Age better tomorrow.
Choose Longevity. Choose DEMAIN Beauty.
Our tips for maintaining a balanced microbiome:
Adopt a healthy lifestyle!
1. A DIET RICH IN FIBER:
Some researchers are talking about 25 fruits and vegetables per week to restore an unbalanced flora.
2. A DIET RICH IN PROBIOTIC STRAINS:
Opt for fermented drinks or foods such as yogurts, olives, pickles, kombucha, kefir, kimcha, etc.
3. SUPPLEMENTATION IN MICROBIOTIC STRAINS:
This type of supplementation can be provided via food supplements rich in pre&probiotics such as those from DEMAIN®.
4. COSMETICS THAT RESPECT YOUR SKIN MICROBIOTA:
This is the choice we made with DEMAIN® with products with 100% natural formulas, without chemical preservatives, enriched with pre&probiotics and with a PH close to 4 to best preserve your body and your skin!
Discover our food supplements:
Scientific studies and sources
De Pessemier B. et al. (2021). Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms, 9(2), 353.
A reference review on the relationship between the gut microbiota and the skin microbiome, as well as the studied links with diet, metabolites, and immune responses.
Sinha S., Lin G., Ferenczi K. (2021). The skin microbiome and the gut-skin axis. Clinics in Dermatology.
Presents the skin microbiome and current research on the gut-skin axis, particularly regarding nutrition, prebiotics, and probiotics.
Wang Z. et al. (2025). Skin microbiome and skin aging: emerging strategies for manipulation. Microbiological Research, 300, 128285.
This review focuses directly on the skin microbiome, the gut-skin axis, and skin aging.
Gut-brain axis and neuroplasticity in health and disease: a systematic review (2024).
A systematic review of 49 human studies examining the relationships between the gut microbiota and the brain, particularly through brain connectivity.
OUR SKINCARE TESTED ON THE SKIN MICROBIOME
At DEMAIN Beauty, the microbiome-friendly approach goes beyond formulation. We also have some of our formulas evaluated by ByomeLab to study their interaction with the skin microbiome and their ability to respect its balance.
ByomeLab
Preserves microbiome diversity
Tests conducted by ByomeLab show that Time To Detox preserves microbiome diversity and, to a certain extent, the balance between two dominant strains, without disrupting an already established microbiome.
Result: Microbiome Respect — Grade A.
Respects microbiome balance
Tests show that Sculpt & Glow preserves microbiome diversity and the balance between two dominant strains, without disrupting an already established microbiome.
Result: Microbiome Respect — Grade A, corresponding in the report to the top 25% of the most microbiome-friendly products.
Preserves microbiome diversity
The ByomeLab evaluation shows that The French Magic Balm preserves microbiome diversity and, to a certain extent, the balance between two dominant strains, without disrupting an already established microbiome.
Result: Microbiome Respect — Grade A.
Preserves the viability and balance of the skin microbiome
The ByomeLab evaluation shows that Go For Protection preserves microbiome viability and maintains the balance of the skin flora.
Result: Microbiome Respect — Grade B.
Targets blemish-associated bacteria while preserving microbiome diversity
ByomeLab tests show that Balance Your Pores exerts a targeted action on certain strains of C. acnes, which are involved in microbiome imbalances in blemish-prone skin, while maintaining S. epidermidis, a bacterium representative of a balanced cutaneous microbiota.
No antimicrobial effect was observed on 8 of the 10 strains studied: the formula therefore acts in a targeted manner without broadly disrupting the diversity of the cutaneous microbiome. The report concludes that Balance Your Pores limits the development of flora associated with blemishes while preserving the diversity of the microbiota.
Result: Microbiome Respect — Grade B.
Targeted action on certain bacteria associated with imbalances in atopic-prone skin.
ByomeLab tests show that Go For Glow strongly limits the growth of various strains of Staphylococcus aureus, a bacterium frequently found in excess in microbiome imbalances of atopic-prone skin.
